Arsenal and Manchester United both need a result when they meet on Sunday as the battle for the top four intensifies.
The Gunners were beaten away at Tottenham last weekend, ensuring they can’t finish above their rivals for the first time since 1995.
Second half goals from Dele Alli and Harry Kane secured a comfortable win for Spurs.
Manchester United were held to a 1-1 draw at home by Swansea, with Gylfi Sigurdsson’s free-kick earning the Welsh side a point.
They are well placed in their Europa League semi-final though, having won 1-0 away to Celta Vigo in the first leg.
Premier League form: Arsenal W3 D0 L2; Manchester United W3 D2 L0
Premier League top scorers
Arsenal – Alexis Sanchez 19 goals
Manchester United – Zlatan Ibrahimovic 17 goals
The meeting between the two earlier in the season finished 1-1, with Olivier Giroud earning Arsenal a late point.
Alexis Sanchez scored twice as Arsenal thrashed United 3-0 in the fixture last term.
Last five Premier League meetings
Manchester United 1 Arsenal 1 – 19/11/16
Manchester United 3 Arsenal 2 – 28/02/16
Arsenal 3 Manchester United 0 – 04/10/15
Manchester United 1 Arsenal 1 – 17/05/15
Arsenal 1 Manchester United 2 – 09/10/14
Granit Xhaka has been ruled out, with Francis Coquelin favourite to take his place in midfield.
Expect Danny Welbeck to return to the starting XI here, with Giroud likely to drop out.
Jose Mourinho has already claimed he will heavily rotate with more than one eye on the Europa League second leg.
Expect the likes of Antonio Valencia, Eric Bailly, Ander Herrera and Marcus Rashford not to be risked here.
Expected starting XI’s
Arsenal (3-4-2-1): Cech; Gabriel, Koscielny, Holding; Chamberlain, Ramsey, Coquelin, Monreal; Sanchez, Ozil; Welbeck
Manchester United (4-3-3): De Gea; Darmian, Smalling, Jones, Blind; Carrick, Pogba; Mata, Mkhitaryan, Martial; Rooney
Result: Arsenal (30/1 with Betfair)*
Correct Score: 2-1 (8/1 with Bet 365)
Anytime Goalscorer: Alexis Sanchez (7/5 with 888 Sport)
*Offer(s) are for new account holders only, other T&C’s apply