Brazil will look to build on their superb record under new manager Tite when they host Paraguay on Wednesday morning.
Brazil recovered from a goal down to thrash Uruguay away from home last time out, with the former Tottenham midfielder Paulinho scoring a hat-trick.
Paraguay kept their qualification hopes alive with a narrow success over Ecuador, with Junior Alonso scoring the winner.
2018 World Cup Qualifying form: Brazil W5 D0 L0; Paraguay W2 D0 L3
2018 World Cup Qualifying top scorers
Brazil – Neymar 5 goals
Paraguay – Dario Lezcano 4 goals
The last four meetings between the two nations have ended in draws, including the reverse fixture in 2018 World Cup qualification.
Last five international meetings
Paraguay 2 Brazil 2 – 30/03/16
Brazil 1 Paraguay 1 – 27/06/15
Brazil 0 Paraguay 0 – 17/07/11
Brazil 2 Paraguay 2 – 09/07/11
Brazil 2 Paraguay 1 – 11/06/09
Thiago Silva remains out of favour, with the Miranda and Marquinhos Tite’s first choice central defensive partnership.
Dani Alves is banned and both Douglas Costa and Gabriel Jesus are out injured for the hosts.
The former Bournemouth winger Juan Iturbe is likely to feature for the visitors.
Expected starting XI’s
Brazil (4-3-3): Alisson; Fagner, Miranda, Marquinhos, Marcelo; Casemiro, Paulinho, Renato Augusto; Coutinho, Neymar, Firmino
Paraguay (4-2-3-1): Silva; Martinez, Da Silva, Valdez, Alonso; Riveros, Caceres; Iturbe, Rejala, Dominguez; Lezcano
Result: Brazil (1/5 with William Hill)
Correct Score: 3-0 (6/1 with William Hill)
Anytime Goalscorer: Roberto Firmino (Evens with Bet 365)