Liverpool will qualify for the group stages of the Champions League if they avoid defeat against Hoffenheim on Wednesday.
Liverpool earned an impressive 2-1 win away from home in the first leg, with Trent Alexander-Arnold scoring a superb free-kick.
A deflected James Milner effort made it 2-0, however Hoffenheim kept themselves in the tie with a late goal.
Liverpool edged past Crystal Palace on the weekend, winning 1-0 thanks to a Sadio Mane winner.
Hoffenheim started their Bundesliga campaign with a 1-0 home success against Werder Bremen.
Jurgen Klopp rotated his side for the Palace game and expect the likes of Arnold, Dejan Lovren, Emre Can and Mohammed Salah to return to the team.
Andrew Robertson impressed versus Palace and is set to keep his spot as the left back.
Hoffenheim have no major injury concerns heading into the game and could name the same XI as the first leg.
Andrej Kramaric missed a penalty in the first leg, but scored the winner versus Bremen so expect the former Leicester man to start here.
Expected starting XI’s
Liverpool (4-3-3): Mignolet; Alexander-Arnold, Lovren, Matip, Robertson; Can, Henderson, Wijnaldum; Salah, Firmino, Mane
Hoffenheim (3-4-2-1): Baumann; Nordtveit, Vogt, Hubner; Kaderabek, Rupp, Demirbay, Zuber; Gnbary, Kramaric; Wagner
Result: Liverpool (4/6 with Sky Bet)
Correct Score: 2-1 (8/1 with Bet Victor)
Anytime Goalscorer: Mohammed Salah (13/10 with Coral)