The second Manchester derby of the season takes place on Thursday with both City and United in need of a result for a Champions League spot.
Manchester City were eliminated by Arsenal in the FA Cup Semi-Final on Sunday, despite Sergio Aguero’s opening goal.
They are in good form domestically though and eased past Southampton last time out, with Vincent Kompany among the scorers.
Manchester United moved to within a point of City after a comfortable 2-0 win away at Burnley on Sunday.
First half goals from Anthony Martial and Wayne Rooney means a top four spot is again in United’s hands.
Premier League form: Manchester City W2 D1 L2; Manchester United W3 D2 L0
Premier League top scorers
Manchester City – Sergio Aguero 17 goals
Manchester United – Zlatan Ibrahimovic 17 goals
Manchester City won at Old Trafford earlier in the season, thanks to early goals from Kevin de Bruyne and Kelechi Iheanacho.
Marcus Rashford was the match winner in the fixture last term, as United secured a famous win at the Etihad.
Last five Premier League meetings
Manchester United 1 Manchester City 2 – 10/09/16
Manchester City 0 Manchester United 1 – 20/03/16
Manchester United 0 Manchester City 0 – 25/10/15
Manchester United 4 Manchester City 2 – 12/04/15
Manchester City 1 Manchester United 0 – 02/11/14
David Silva is a major doubt after injury forced him off early against Arsenal on Sunday.
Gabriel Jesus is in line for a surprise start here, although Aguero will keep his spot if the Brazilian isn’t fit enough.
Paul Pogba has been ruled out for United here, meaning Marouane Fellaini is likely to play.
Antonio Valencia and Henrik Mkhitaryan were rotated against Burnley, but both will start.
Expected starting XI’s
Manchester City (4-2-3-1): Bravo; Navas, Otamendi, Kompany, Clichy; Toure, Fernandinho; Sterling, De Bruyne, Sane; Gabriel Jesus
Manchester United (4-2-3-1): De Gea; Valencia, Bailly, Blind, Darmian; Herrera, Fellaini; Lingard, Mkhitaryan, Martial; Rashford
Result: Manchester City (10/11 with Bet 365)
Correct Score: 2-1 (15/2 with Bet 365)
Anytime Goalscorer: Kevin de Bruyne (13/4 with 888 Sport)