Tottenham will look to increase the pressure on Jose Mourinho when they travel to Old Trafford on Monday.
Manchester United were embarrassingly bad away at Brighton last time out, losing 3-2 at the Amex.
Romelu Lukaku opened his account for the campaign, however they left themselves too much to do having conceded three before half-time.
Tottenham recorded a comfortable victory over Fulham to extend their 100% start to the season.
Harry Kane ended his August drought with the killer third for Tottenham.
Tottenham have a poor record at Old Trafford under Mauricio Pochettino, losing on all four previous visits.
They did arguably produce their best performance of the league season in the reverse fixture, easing to a 2-0 win at Wembley.
Last five Premier League meetings
Tottenham 2 Manchester United 0 – 31/01/18
Manchester United 1 Tottenham 0 – 28/10/17
Tottenham 2 Manchester United 1 – 14/05/17
Manchester United 1 Tottenham 0 – 11/12/16
Tottenham 3 Manchester United 0 – 10/04/16
United could revert to a back three here, with Chris Smalling featuring in the defence.
They could also have Nemanja Matic, Alexis Sanchez and Antonio Valencia back in the XI.
Hugo Lloris’ involvement is in doubt after the Spurs keeper was charged with drink driving in the week.
Toby Alderweireld should start against the side he was heavily linked with, whilst Son Heung-Min remains on international duty.
Expected starting XI’s
Manchester United (3-5-2): De Gea; Bailly, Smalling, Lindelof; Valencia, Pogba, Matic, Lingard, Young; Lukaku, Sanchez
Tottenham (3-5-2): Vorm; Sanchez, Alderweireld, Vertonghen; Trippier, Dele, Dier, Eriksen, Davies; Kane, Moura
Result: Manchester United (13/8 with Betfred)
Correct Score: 1-0 (8/1 with Bet 365)
Anytime Goalscorer: Alexis Sanchez (14/5 with 888 Sport)