Two sides with little to play for meet on Sunday as Southampton host second placed Manchester City.
Southampton eased past relegation threatened Watford last time out, with Danny Ings scoring another brace.
James Ward-Prowse sealed the win late on with a superb free-kick to leave Southampton 14th going into this fixture.
Manchester City may have lost their title; however they thrashed the new champions Liverpool 4-0 on Thursday.
Kevin de Bruyne, Raheem Sterling and Phil Foden scored in a dominant first half, before an Alex Oxlade-Chamberlain own goal after the break.
Premier League form: Southampton W2 D0 L3; Manchester City W3 D0 L2
Premier League top scorers
Southampton – Danny Ings 18 goals
Manchester City – Sergio Aguero 16 goals
Manchester City scored twice late on in the reverse fixture to edge past Southampton.
Manchester City have an excellent recent record against Southampton, winning the last seven in all competitions.
Last five Premier League meetings
Manchester City 2 Southampton 1 – 02/11/19
Southampton 1 Manchester City 3 – 30/12/18
Manchester City 6 Southampton 1 – 04/11/18
Southampton 0 Manchester City 1 – 13/05/18
Manchester City 2 Southampton 1 – 29/11/17
Jack Stephens and Moussa Djenepo are both available again after serving suspensions.
Sofiane Boufal and Pierre-Emile Hojbjerg remain doubtful having missed the Watford win.
Manchester City are likely to rotate the squad again having had a heavy schedule since footballs return.
David Silva, Riyad Mahrez and Bernardo Silva are all set to come into the XI.
Expected starting XI’s
Southampton (4-4-2): McCarthy; Walker-Peters, Bednarek, Stephens, Bertrand; Armstrong, Ward-Prowse, Hojbjerg, Redmond; Ings, Long
Manchester City (4-3-3): Ederson; Walker, Otamendi, Laporte, Zinchenko; D.Silva, Rodri, B.Silva; Mahrez, Jesus, Sterling
Result: Manchester City (3/10 with Bet 365)
Correct Score: 1-3 (11/1 with Bet 365)
Anytime Goalscorer: Gabriel Jesus (23/20 with Coral)
Odds correct at time of article (04/07, 19:00), they are subject to change