Arsenal require a miracle to overturn their first leg Champions League deficit against Bayern Munich.
Munich thrashed the Gunners 5-1 in the Alianz Arena three weeks ago, scoring four in the second half.
Arsenal were beaten away at Liverpool on the weekend, losing 3-1 at Anfield which has severely dented their top four hopes.
Alexis Sanchez was dropped to the bench and despite an improved display when he was introduced at the break, it was too late for the Gunners.
Bayern Munich eased to a 3-0 success away at Cologne, taking a giant step towards the Bundesliga title.
Javier Martinez opened the scoring as Munich stretched their advantage to seven points at the top.
Champions League form: Arsenal W3 D1 L1; Bayern Munich W4 D0 L1
Champions League top scorers
Arsenal – Mesut Ozil 4 goals
Bayern Munich – Robert Lewandowski 6 goals
Bayern Munich eliminated Arsenal at the last 16 stage of the competition in both 2013 and 2014.
The two also met in the group stage last year, with both teams winning the home fixtures.
Last five Champions League meetings
Bayern Munich 5 Arsenal 1 – 14/02/16
Bayern Munich 5 Arsenal 1 – 04/11/15
Arsenal 2 Bayern Munich 0 – 20/10/15
Bayern Munich 1 Arsenal 1 – 11/03/14
Arsenal 0 Bayern Munich 2 – 19/02/14
Both teams to score – 1/2 with Betfair
Mesut Ozil remains a big doubt after illness ruled him out of the trip to Anfield on Saturday.
Santi Cazorla and Mohamed Elneny are both ruled for the hosts.
Philipp Lahm is suspended for Bayern Munich, with Rafinha expected to deputise.
Renato Sanches, Douglas Costa and Jerome Boateng are all doubts for Munich and are unlikely to be risked given the strong advantage.
Expected starting XI’s
Arsenal (4-2-3-1): Ospina; Bellerin, Mustafi, Koscielny, Monreal; Coquelin, Xhaka; Chamberlain, Iwobi, Sanchez; Giroud
Bayern Munich (4-3-3): Neuer; Rafinha, Martinez, Hummels, Bernat; Thiago, Alonso, Kimmich; Robben, Lewandowski, Muller
Result: Bayern Munich (6/5 with Bet 365)
Correct Score: 1-2 (8/1 with Bet 365)
Anytime Goalscorer: Robert Lewandowski (42/41 with 888 Sport)