Atletico Madrid need to overturn a three goal deficit against their city rivals Real if they are to reach the Champions League final.
Cristiano Ronaldo scored a superb hat-trick in the first leg to help Real Madrid take total control of the tie.
Atletico eliminated Leicester City in the Quarter-Finals, whilst Real needed extra-time to overcome the German champions Bayern Munich.
Saul Niguez scored the only goal as Atletico edged past Eibar on the weekend to cement third spot in La Liga.
A rested Real side were too strong for Granada, easing to a 4-0 win away against the relegated side.
Enhanced match odds
Real Madrid to qualify for the final: 3/1 with Betfair*
Real Madrid to qualify for the final: 3/1 with Paddy Power*
Champions League form: Atletico Madrid W2 D2 L1; Real Madrid W4 D0 L1
Champions League top scorers
Atletico Madrid – Antoine Griezmann 5 goals
Real Madrid – Cristiano Ronaldo 10 goals
Real Madrid took four points off Atletico Madrid domestically this season, including a convincing 3-0 win away from home.
Real have also beaten Atletico in two of the last three Champions League finals, winning on penalties in 2016.
Last five meetings
Real Madrid 3 Atletico Madrid 0 – 02/05/16
Real Madrid 1 Atletico Madrid 1 – 09/04/16
Atletico Madrid 0 Real Madrid 3 – 19/11/16
Real Madrid 1 Atletico Madrid 1 (Real Madrid won on pens) – 28/05/16
Real Madrid 0 Atletico Madrid 1 – 27/02/16
Under 2.5 goals – 43/40 with Bet 365
Lucas Hernandez is set to start from right back given Atletico’s defensive injuries in that position.
Diego Godin is banned domestically but will start on Wednesday evening.
Real Madrid are likely to start Nacho ahead of Danilo, with Dani Carvajal out for the remainder of the season.
Isco is expected to get the nod once again with Gareth Bale unlikely to be fit enough.
Expected starting XI’s
Atletico Madrid (4-4-2): Oblak; Hernandez, Savic, Godin, Felipe Luis; Carrasco, Saul, Gabi, Koke; Griezmann, Gameiro
Real Madrid (4-3-3): Navas; Nacho, Ramos, Varane, Marcelo; Kroos, Casemiro, Modric; Isco, Benzema, Ronaldo
Result: Draw (13/5 with Bet 365)
Correct Score: 1-1 (7/1 with Paddy Power)
Anytime Goalscorer: Diego Godin (8/1 with Betfred)
*Offer(s) are for new account holders only, other T&C’s apply