Arsenal need to win when they travel to face Southampton on Wednesday in the Premier League.
Southampton earned a goalless draw away at Liverpool on the weekend, with Fraser Forster saving a James Milner penalty.
The result means Southampton have kept clean sheets in all four fixtures against the Reds this term.
Arsenal were too strong for Manchester United on the same day as they maintained a push for a Champions League spot.
A deflected Granit Xhaka effort was doubled by Danny Welbeck against his former employers.
Enhanced match odds
Premier League form: Southampton W1 D2 L2; Arsenal W3 D0 L2
Premier League top scorers
Southampton – Charlie Austin & Nathan Redmond 6 goals each
Arsenal – Alexis Sanchez 19 goals
The two sides have already met in three different competitions this season.
Southampton eliminated Arsenal on route to the Capital One Cup final, however the Gunners thrashed the Saints in the FA Cup.
Last five Premier League meetings
Arsenal 2 Southampton 1 – 10/09/16
Arsenal 0 Southampton 0 – 02/02/16
Southampton 4 Arsenal 0 – 26/12/15
Southampton 2 Arsenal 0 – 01/01/15
Southampton 2 Arsenal 2 – 28/01/14
Charlie Austin is closing in on a return, however is unlikely to feature here.
Nathan Redmond is expected to start ahead of Sofiane Boufal in probably the only change from the Anfield draw.
Shkodran Mustafi is likely to return to the team here, with Kieran Gibbs dropping out.
After his goal on Sunday, Welbeck is expected to keep his place up front ahead of Olivier Giroud.
Expected starting XI’s
Southampton (4-3-3): Forster; Soares, Stephens, Yoshida, Bertrand; Ward-Prowse, Romeu, Davis; Tadic, Gabbiadini, Redmond
Arsenal (3-4-3): Cech; Mustafi, Koscielny, Holding; Chamberlain, Ramsey, Xhaka, Monreal; Sanchez, Welbeck, Ozil
Result: Draw (14/5 with Bet 365)
Correct Score: 1-1 (7/1 with Coral)
Anytime Goalscorer: Alexis Sanchez (4/3 with 888 Sport)
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