Two of the top four meet in the Saturday evening fixture as Brighton & Hove Albion entertain the champions Manchester City.
Brighton have drawn their last three matches and were frustrated in the 0-0 draw at bottom side Norwich City last weekend.
Neal Maupay missed an excellent late chance, however a draw was a fair result in an even fixture.
Manchester City eased past Burnley with Kevin de Bruyne among the scorers for the hosts.
They then thrashed Club Brugge 5-1 in the Champions League, with Riyad Mahrez scoring twice.
Premier League form: Brighton W2 D3 L0; Manchester City W3 D2 L0
Premier League top scorers
Brighton – Neal Maupay 4 goals
Manchester City – Four players 2 goals each
Brighton ended a run of seven consecutive defeats to Manchester City when they the last fixture, rallying from 2-0 down.
Prior to that though, City had won on their three previous visits to the Amex, scoring 11 goals in the process.
Last five Premier League meetings
Brighton 3 Manchester City 2 – 18/05/21
Manchester City 1 Brighton 0 – 13/01/21
Brighton 0 Manchester City 5 – 11/07/20
Manchester City 4 Brighton 0 – 31/08/19
Brighton 1 Manchester City 4 – 12/05/19
Adam Webster, Danny Welbeck and Steven Alzate will miss the visit of the champions.
Tariq Lamptey will run Joel Veltman close for the right wing-back role, but the Dutchman may well continue.
Ferran Torres is the only injured player for City and the likes of Foden and De Bruyne will likely continue having been subbed early in midweek.
Ilkay Gundogan and Gabriel Jesus could well continue on the bench here.
Expected starting XI’s
Brighton (3-5-2): Sanchez; Duffy, Dunk, Burn; Veltman, Gross, Bissouma, Lallana, Cucurella; Maupay, Trossard
Manchester City (4-3-3): Ederson; Walker, Dias, Laporte, Cancelo; De Bruyne, Rodri, Bernardo; Mahrez, Foden, Grealish
Result: Manchester City
Manchester City have won seven of the eight meetings between the two since Brighton were promoted to the Premier League
Correct Score: 0-2
Manchester City have kept six clean sheets in eight Premier League matches this season
Anytime Goalscorer: Phil Foden
Phil Foden scored in both meetings last term and is likely to start in the false nine role