One of Hamburg or Wolfsburg will be in the Bundesliga relegation play-off and the pair meet in a deciding fixture on Saturday.
Wolfsburg need to avoid defeat to ensure they are safe, whilst a Hamburg win will see them move above their opponents who would drop into the play-off.
Hamburg have ended the season poorly, claiming just two points from their last five games.
Wolfsburg were held to a 1-1 draw by Borussia Monchengladbach last time out, requiring a Mario Gomez equaliser.
Bundesliga form: Hamburg W0 D2 L3; Wolfsburg W2 D1 L2
Bundesliga top scorers
Hamburg – Four players on 5 goals
Wolfsburg – Mario Gomez 16 goals
Hamburg will be without key striker Pierre Michel Lasogga on Saturday, meaning Billy Wood will deputise.
Dennis Diekmeier is banned for the hosts, who are also without keeper Rene Adler.
Wolfsburg are without the banned Riechedly Bazoer and Ricardo Rodriguez is also a big doubt.
Luis Gustavo is again set to feature in central defence for the visitors.
Expected starting XI’s
Hamburg (4-2-3-1): Mathenia; Sakai, Papadopoulous, Mavraj, Oztrzolek; Jung, Janjicic; Jatta, Holtby, Kostic; Wood
Wolfsburg (4-2-3-1): Casteels; Jung, Knoche, Gustavo, Gerhardt; Guilavogui, Arnold; Vieirinha, Didavi, Ntep; Gomez
Result: Draw (12/5 with Bet 365)
Correct Score: 2-2 (14/1 with Paddy Power)
Anytime Goalscorer: Mario Gomez (13/8 with Paddy Power)