Two of the top six go head to head on Tuesday evening as Manchester United entertain Everton.
A injury hit United side were held at Old Trafford again on Saturday as they drew 0-0 at home to West Brom.
The draw means United are five points adrift of the Champions League places, although they do have a game in hand.
Everton were beaten once again by their city rivals Liverpool, going down 3-1 at Anfield, despite Matthew Pennington’s goal.
Philippe Coutinho was in excellent form and he scored one and made another for an in-form Reds.
Premier League form: Manchester United W3 D2 L0; Everton W3 D0 L2
Premier League top scorers
Manchester United – Zlatan Ibrahimovic 15 goals
Everton – Romelu Lukaku 21 goals
A late Leighton Baines penalty earned Everton a point when the pair met earlier in the season, as he cancelled out a Zlatan Ibrahimovic goal.
Last five Premier League meetings
Everton 1 Manchester United 1 – 04/12/16
Manchester United 1 Everton 0 – 03/04/16
Everton 0 Manchester United 3 – 15/10/15
Everton 3 Manchester United 0 – 26/04/15
Manchester United 2 Everton 1 – 05/10/14
Ander Herrera and Zlatan Ibrahimovic both return from bans and are set to start on Tuesday evening.
Michael Carrick could be rotated, although with Paul Pogba likely to miss out this is unlikely.
Everton remain without the injured Seamus Coleman and Ramiro Funes Mori with the pair set to miss the rest of the campaign.
Ross Barkley was criticised for his performance against Liverpool, but he is set to keep his spot in the side.
Expected starting XI’s
Manchester United (4-2-3-1): De Gea; Valencia, Bailly, Rojo, Young; Herrera, Carrick; Lingard, Mkhitaryan, Martial; Ibrahimovic
Everton (4-3-3): Robles; Holgate, Williams, Jagielka, Baines; Gueye, Davies, Barkley; Mirallas, Lukaku, Calvert-Lewin
Result: Manchester United (4/7 with William Hill)
Correct Score: 2-1 (33/4 with 888 Sport)
Anytime Goalscorer: Zlatan Ibrahimovic (13/14 with 888 Sport)