Barcelona need a result away at Real Madrid in the El Clasico as the pair go head to head for the La Liga table.
Isco’s last minute winner helped Madrid edge past Sporting Gijon last time out and remain clear at the top.
They also progressed in the Champions League, needing extra-time to overcome the German champions Bayern Munich.
Barcelona’s run in that competition came to an end at the Quarter-Final stage, after a goalless draw at the Nou Camp at home to Juventus.
Lionel Messi scored twice as they beat Real Sociedad last weekend to remain three points behind Madrid, who also have a game in hand.
Enhanced match odds
La Liga form: Real Madrid W4 D1 L0; Barcelona W4 D0 L1
La Liga top scorers
Real Madrid – Cristiano Ronaldo 19 goals
Barcelona – Lionel Messi 29 goals
Sergio Ramos scored a late header to rescue a point for Madrid in the fixture earlier in the season.
In the fixture last year, Barcelona embarrassed Madrid at the Bernabeu, easing to a 4-0 success on route to the title.
Last five La Liga meetings
Barcelona 1 Real Madrid 1 – 03/12/16
Barcelona 1 Real Madrid 2 – 02/04/16
Real Madrid 0 Barcelona 4 – 21/11/15
Barcelona 2 Real Madrid 1 – 22/03/15
Real Madrid 3 Barcelona 1 – 25/10/14
Real Madrid hope to have Gareth Bale back after the Welshman missed the second leg with Bayern in the week.
Both Pepe and Raphael Varane are out though, meaning Nacho will partner Ramos in defence.
Neymar is banned for Barcelona who are likely to line up with a 3-5-2 formation on Sunday.
Arda Turan has struggled for fitness in recent weeks and Barcelona will alsobe without Aleix Vidal and Rafinha.
Expected starting XI’s
Real Madrid (4-3-3): Navas; Carvajal, Ramos, Nacho, Marcelo; Modric, Casemiro, Kroos; Bale, Benzema, Ronaldo
Barcelona (3-5-2): Ter Stegen; Pique, Mascherano, Umtiti; Roberto, Rakitic, Busquets, Iniesta, Alba; Messi, Suarez
Result: Draw (3/1 with Bet 365)
Correct Score: 2-2 (11/1 with William Hill)
Anytime Goalscorer: Luis Suarez (5/4 with Betfair)
*Offer(s) are for new account holders only, other T&C’s apply