Fifth meets third on Wednesday evening as Manchester United welcome an in-form Tottenham to Old Trafford.
Manchester United were held to a 0-0 draw at home by Newcastle United on Sunday.
Joelinton missed two good chances for Newcastle; however they were hanging on towards the end with Marcus Rashford spurning a superb opportunity.
Tottenham recorded a seventh win in 10 this season as they comfortably beat Everton on Saturday.
A Harry Kane penalty was doubled by a late Pierre-Emile Højbjerg effort.
Premier League form: Manchester United W3 D1 L1; Tottenham W4 D0 L1
Premier League top scorers
Manchester United – Marcus Rashford 3 goals
Tottenham – Harry Kane 9 goals
Manchester United won both meetings last term, including a 3-2 home success with Cristiano Ronaldo scoring a hat-trick.
Spurs do have two recent wins at Old Trafford though, most notably a 6-1 win back in 2020, with both Heung Min Son and Kane scoring twice.
Last five Premier League meetings
Manchester United 3 Tottenham 2 – 12/03/22
Tottenham 0 Manchester United 3 – 30/10/21
Tottenham 1 Manchester United 3 – 11/04/21
Manchester United 1 Tottenham 6 – 04/10/20
Tottenham 1 Manchester United 1 – 19/06/20
Christian Eriksen missed the draw with Newcastle through illness and is a doubt for the visit of his former side.
Rashford should return to the XI and this will likely see Ronaldo drop to the substitutes bench.
Richarlison suffered an injury against Everton on Saturday and is ruled out here.
Spurs will likely deploy a 3-5-2 formation with Dejan Kulusevski unlikely to return.
Expected starting XI’s
Manchester United (4-3-3): De Gea; Dalot, Varane, Martinez, Shaw; Casmeiro, Eriksen, Fernandes; Anthony, Rashford, Sancho
Tottenham (3-5-2): Lloris; Romero, Dier, Lenglet; Doherty, Bissouma, Hjojberg, Bentancur, Sessegnon; Kane, Son
Likely to be little separating the two teams on Wednesday evening
Correct Score: 1-1
Both teams will likely score meaning 1-1 or 2-2 is the best bet
Anytime Goalscorer: Marcus Rashford
He has made a good start to the season and has four in his last seven matches against Tottenham